Integrin Cytoplasmic Region-binding Proteins.
نویسندگان
چکیده
منابع مشابه
Integrin cytoplasmic domain-binding proteins.
Integrins are a large family of cell surface receptors that mediate cell adhesion and influence migration, signal transduction, and gene expression. The cytoplasmic domains of integrins play a pivotal role in these integrin-mediated cellular functions. Through interaction with the cytoskeleton, signaling molecules, and other cellular proteins, integrin cytoplasmic domains transduce signals from...
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Article Chronology:Received 28 March 2006Revised version received6 June 2006Accepted 13 June 2006Available online 29 June 2006The three Kindlins are a novel family of focal adhesion proteins. The Kindlin-1 (URP1) gene ismutated in Kindler syndrome, the first skin blistering disease affecting actin attachment inbasal keratinocytes. Kindlin-2 (Mig-2), the best stud...
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Platelet agonists increase the affinity state of integrin a IIb b 3 , a prerequisite for fibrinogen binding and platelet aggregation. This process may be triggered by a regulatory molecule(s) that binds to the integrin cytoplasmic tails, causing a structural change in the receptor. b 3 -Endonexin is a novel 111–amino acid protein that binds selectively to the b 3 tail. Since b 3 -endonexin is p...
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Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic inte...
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Vimentin, an intermediate filament protein induced during epithelial-to-mesenchymal transition, is known to regulate cell migration and invasion. However, it is still unclear how vimentin controls such behaviors. In this study, we aimed to find a new integrin regulator by investigating the H-Ras-mediated integrin suppression mechanism. Through a proteomic screen using the integrin β3 cytoplasmi...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1998
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.9.375